Altered Expression of STAT3, RORγt, and IL-17A Proteins and Th17 Cell in Intrahepatic Cholestasis of Pregnancy

Background: Intrahepatic cholestasis of pregnancy (ICP) is a disorder specifically associated with pregnancy. Recent evidence suggests that the T helper 17 (Th17) cell population related to maternal and foetal immune imbalance ICP. However, there has been insufficient attention paid potential roles signal transducer activator transcription 3 (STAT3) RAR-related orphan receptor gamma (RORγt) in modulations Th17 Accordingly, purpose our study was investigate alterations placenta peripheral blood patients ICP correlations between STAT3, RORγt, interleukin (IL)-17A Methods: Nine pregnant women nine normal served as control groups, respectively. IL-17A expression were examined by immunohistochemistry western blotting placental tissue. Flow cytometry used quantify circulation. We compared data groups using Chi-square tests or paired t tests. Pearson Spearman coefficients measure correlations. Results: mainly expressed trophoblasts two patients. Comparatively group, levels proteins significantly elevated blood. Moreover, protein level showed positive relationships STAT3 (r = 0.97, p 2e-05) RORγt 0.91, 0.01) however, not group (STAT3, r 0.5, 0.17; 0.62, 0.07). Conclusions: Women an increase cells comparison pregnancies. may proliferation differentiation, appears be altered adversely affected excessive accumulation cell.